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| Sp100 nuclear antigen ： ウィキペディア英語版 |
Sp100 nuclear antigen
Sp100 nuclear antigen is an interferon stimulated antigen found in the bile duct of primary biliary cirrhosis. Histologically sp100 'dots' regions of the cell nucleus. Viral infection and mitogens affect the expression of the Sp100 autoantigen. Cells grown in the presence of interferons (α, β, and γ) revealed an increase both in size and number of the Sp100 protein-containing nuclear dots and increase the protein concentration.
This raises "the question whether cytokine-mediated increase of Sp100 protein expression plays a role in induction of anti-Sp100 autoantibodies."
== Sp100 and nuclear dots ==
Two proteins, sp100 and promyelocytic leukemia (PML) factor are localized to punctate domains in the nucleus (nuclear dots or nuclear bodies). These domains (few to 20) were found to form a donut shaped structure when cells were starved of amino acids. In particular, depravation of cystine results in most pronounced changes. Two other proteins, PIC1/SUMO-1, that also interact with nuclear pore complex factors also interact with these two proteins. In addition sp100 interacts with a chromatin binding protein, HM1.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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